What is 1P-LSD?
1P LSD stands for 1-propionyl-lysergic acid diethylamide. It’s a derivative of LSD — which essentially means it’s a modified version of the classic LSD-25 that Albert Hofmann discovered in 1943.
This molecule is differentiated from LSD by a propionyl group attached to the nitrogen molecule in the indole portion of LSD. The central indole molecule of LSD is the characterizing element of the molecule that’s shared with all other tryptamine-based psychedelics (such as DMT or psilocybin).
1P-LSD itself is only mildly psychedelic. It has a 67-fold less binding affinity for the 5-HT1A receptors, 13-fold less activity at the 5-HT2A receptors, and a 3.5-fold increase at h5-HT2C receptors than LSD-25 .
However, 1P-LSD is a prodrug for LSD, which means it’s converted to LSD by the liver, which then goes on to produce psychoactive effects . The bioavailability of LSD from 1P-LSD is nearly 100%.
Where Did 1P-LSD Come From?
Since the prohibition of LSD and other psychedelics in 1966, chemists have been seeking to discover new psychedelic “research chemicals” or “designer drugs.”
Researchers like Alexander Shulgin and Dr. David E. Nichols (Purdue University) have made a lot of progress over the years.
It’s unclear when 1P-LSD was first invented and by whom — but it was first officially reported in 2015 by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA).
This compound entered the market as a “legal LSD alternative” in the mid-2010s without any previous mention in scientific literature. Whoever invented it didn’t publish anything about it and has made no attempt to take credit for their discovery.
1P LSD first appeared on the online research chemical market in January 2015. Although it was likely discovered in an academic setting, it is unknown who first synthesized 1P-LSD, as the substance does not appear in any academic literature pre-dating its arrival on the research chemical market. Interestingly, the future usage of 1-akylated lysergamide derivatives as a means to bypass controlled substance laws banning LSD as a precursor was foreseen in a DEA report from 1988:
What’s The Dose of 1P-LSD?
The dose of 1P-LSD is equivalent to LSD. There have never been any studies on the effective dose of 1P-LSD.
However, with recent findings that 1P-LSD is converted to LSD at a rate of nearly 100%, the psychoactive dose would be identical to that of LSD:
- Microdose — 10–20 micrograms
- Standard Psychoactive Dose — 80–200 micrograms
- Heroic Dose — 200–400 micrograms
What Does 1P-LSD Feel Like?
The effects of 1P-LSD are virtually identical to that of LSD. The only difference is that it can take a little bit longer for the effects to kick in. This is because the 1P-LSD needs to first be metabolized by the liver and turned into LSD.
The experience can vary widely depending on your internal mental state. If you’re depressed or anxious going into the experience, 1P-LSD is going to inflate this even further. Likewise, if you feel excited, positive, and curious, 1P-LSD is going to expand this state of consciousness even further.
This is exactly why the concept of set (mindset) and setting (the environment and people you’re with during the trip) is so important. Going into the experience with a negative attitude, which can include fear, anxiety, or depression, will ultimately lead to a more challenging experience and may even pose psychological harm.
The positive effects of 1P-LSD and other LSD analogs:
- Hallucinations
- Euphoria
- Synesthesia
- Remembrance of significant life events
- Mystical experiences
- Ego-dissolution
- Cathartic experiences
- Deep-reaching insightful experiences
- A strong sense of awe & wonder
- Altered perception of time
- Laughter
The negative effects of 1P-LSD and other LSD analogs:
- Paranoia
- Reliving past traumatic experiences
- Anxiety
- Believing people are “out to get you”
- Confusion and frustration when performing routine tasks
- Feelings of being overwhelmed
- Triggering of psychosis or other mental illness
These negative effects can’t always be avoided, but they can be significantly reduced by following our guidelines for the responsible use of psychedelics.
How Long Does 1P-LSD Last?
1P-LSD lasts roughly the same amount of time as LSD (6 – 10 hours).
After taking 1P-LSD, it’s converted to LSD. This happens quickly but prolongs the amount of time needed for the effects to appear. LSD usually takes less than 30 minutes to kick in, while 1P-LSD can take up to an hour and a half (usually around an hour). This also extends the total duration of the trip.
The estimated duration of effects for acid is 6 to 10 hours, which means 1P-LSD is roughly 7 to 11 hours when you account for this difference.
How to Take 1P-LSD
1P-LSD is taken the same way as LSD. It’s spread out over a square of blotter paper and then held under the tongue for 10 or 15 minutes before swallowing it whole.
The active ingredients are absorbed through the capillaries under the tongue, directly into the bloodstream.
Most people hold LSD under the tongue for faster onset of effects because it allows it to enter the bloodstream directly — rather than having to travel through the digestive tract first.
However, 1P-LSD may actually kick in faster if you swallow the tab instead.
This is because, unlike acid, this psychedelic needs to be activated by the liver. When you absorb compounds like this through the gut, they’re sent directly to the liver, which does a “first-pass metabolism” before entering the systemic circulation.
How Strong is 1P-LSD Compared To Other Psychedelics?
1P-LSD is one of the strongest psychedelics, gram for gram, on Earth. This is a title held by all psychoactive LSD derivatives, which are profoundly psychoactive at sub-milligram doses.
For example, the dose of 1P-LSD is around 200 micrograms, which is about 0.2 milligrams. Compare this to psilocybin (the active ingredient in magic mushrooms), which is closer to 10 milligrams. 5-MeO-DMT, the active ingredient in the Bufo alvarius toad (another powerful psychedelic), has a dose of around 8 milligrams, and N,N-DMT, the active ingredient in ayahuasca, is nearly 50 mg.
1P LSD vs LSD
LSD is the classic version of LSD invented by Albert Hofmann in the 1940s. It’s the compound that was popularized during the 1960s and beyond by people like Timothy Leary, Richard Alpert (Ram Dass), Nicolas Sand, Tim Sully, Ralph Metzner, and others.
Compared to LSD-25, 1P-LSD is virtually indistinguishable. There are some reports that 1P-LSD is weaker, others suggesting it’s stronger. The consensus is that the two are identical in terms of their effects and dosage.
1P-LSD vs. ALD-52
1P-LSD is a homolog of this ALD-52, which means it’s virtually identical aside from having an extra carbon atom.
Technically speaking, 1P-LSD has a propionyl group attached to the nitrogen atom in the indole group, while ALD-52 has an acetyl group instead.
The effects of these two molecules are essentially identical.
Is 1P-LSD Safe?
There have never been any clinical studies on 1P-LSD to confirm its safety in humans, and this compound has only been on the market for a couple of years now.
With that said, there have never been any reported cases of toxicity or deaths associated with this compound. Preliminary research suggests it shares the same effect profile and safety as LSD-25 — a compound with copious amounts of research proving the high safety incidence of this compound.
Responsible Use of Psychedelics
As is the case with all psychedelics, it’s critical that you understand how to stay safe with these compounds before you begin. While there isn’t much of a risk in terms of physical side effects, these substances carry the risk of psychological harm.
People with a history of psychosis, schizophrenia, or other mental illness should always consult a psychologist before using psychedelics. While there’s some indication these compounds can help treat mental illness, this needs to be done in a controlled setting under the supervision of a psychotherapist. In this environment, it’s more likely that LSD-25, psilocybin, or 5-MeO-DMT will be used instead of 1P-LSD due to a lack of clinical research.
Risk of Adulteration
One of the benefits of buy 1P LSD is its lighter legal restrictions. While this psychedelic isn’t technically legal, it isn’t illegal either (in most places). This means it’s easier to find a legit supplier than it is for overtly prohibited compounds. You can order 1P-LSD from reputable names like Sigma Aldrich, or other brand name suppliers, which significantly decreases the chance of adulteration with potentially harmful compounds.
You don’t need to use the black market to buy this stuff. Blackmarket vendors dramatically increase the risk of ordering fake 1P LSD for sale, which often use NBOMe compounds instead — which are dangerous. There have been many deaths associated with this compound in the past.
1P-LSD is a semisynthetic compound of the lysergamide family. It is similar to LSD and is named for the propionyl group bound to the nitrogen of the polycyclic indole group of LSD. Propionyl consists of the carbonyl chain CH3CH2CO- bound to an amino group. 1P-LSD is homologous to ALD-52, which holds an acetyl group bound to the nitrogen instead of the propionyl group bound at the same location. The structure of 1P-LSD contains a polycyclic group featuring a bicyclic hexahydro indole bound to a bicyclic quinoline group. At carbon 8 of the quinoline, an N,N-diethyl carboxamide is bound.
A 2020 study on two human male volunteers found that the levels of 1P-LSD in the serum after administration quickly diminished within the first hour while LSD has been found consistently during the experiment, which further supports the prodrug theory. The study also found that LSD’s bioavailability after oral ingestion of 1P LSD was close to 100%.
Additionally, it has been theorized that 1P LSD may act as a prodrug of LSD. This is further concluded via a LC-MS where LSD is detected when 1P LSD is incubated in human serum. Thus far it remains unclear if 1P LSD is hydrolyzed to LSD in vivo.
Physical effects
- Stamina enhancement – This is generally mild in comparison to the stamina enhancement produced by traditional stimulants.
- Appetite suppression
- Bodily control enhancement
- Difficulty urinating
- Excessive yawning – This effect is significantly less pronounced than it is with psilocybin and its related compounds, the four-position substituted tryptamines.
- Nausea – Mild nausea is occasionally reported when consumed in moderate to high dosages and either passes instantly soon after the user has vomited or gradually fades by itself as the peak sets in.
- Increased blood pressure
- Increased heart rate
- Increased perspiration
- Muscle contractions
- Muscle spasms
- Pupil dilation
- Increased salivation
- Vasoconstriction – Vasoconstriction may lead to users feeling cold, especially in the extremities.
- Seizure – The likelihood is largely extrapolated from the seizures that have been reported from the use of LSD.
1p LSD effects(Cognitive)
- Catharsis
- Conceptual thinking
- Creativity enhancement
- Emotion enhancement
- Novelty enhancement
- Personal bias suppression
- Personal meaning enhancement
- Focus enhancement – This effect is experienced exclusively on low or threshold dosages and feels less forced than it does with stimulants.
- Immersion enhancement
- Suggestibility enhancement
- Cognitive euphoria – This component is, generally speaking less consistent and pronounced than it is with substances like psilocybin and MDMA. The mental euphoria experienced on LSD is usually simply due to an enhancement of the user’s current psychological and emotional state coupled with its more regularly occurring effect, physical euphoria.
- Delusion
- Déjà vu
- Increased libido
- Increased music appreciation
- Increased sense of humor
- Laughter fits – This can manifest prominently during a 1P LSD experience, particularly during the come up phase, often resulting in bouts of uncontrollable giggles and laughter that can form a feedback loop if around others who are also under the influence.
- Memory suppression
- Thought acceleration
- Thought disorganization
- Thought loops
- Time distortion
- Wakefulness
Hallucinatory states
1P-LSD is capable of producing a full range of hallucinatory states in a fashion that is significantly less consistent and reproducible than that of many other commonly used psychedelics, specifically tryptamines like DMT, bufo alvarius, 5 meo, 5 meo dmt, dmt for sale, buy dmt, buy dmt online usa, bufo alvarius for sale or psilocybin mushrooms, buy psychedelics, legal psychedelics online, penis envy mushrooms. These effects include:
- Transformations
- Machinescapes – This component is a rare effect that typically only occurs at very strong to heavy doses, and not as consistently as with notably visual psychedelics like DMT, ETH-LAD, and 2C-P, and atypical psychedelics like salvia.
- Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) – Although 1P-LSD is technically capable of producing hallucinatory states in a fashion that is on par with psilocin, magic shrooms, penis envy, golden teacher, buy mushrooms, mushrooms for sale, psilocybe cubensis, psychedelic mushrooms or DMT, bufo alvarius, 5 meo, 5 meo dmt, dmt for sale, buy dmt, buy dmt online usa, bufo alvarius for sale in its vividness and intensity, these effects are incredibly rare and inconsistent in comparison. While traditional psychedelics such as LSA, ayahuasca, buy ayahuasca, ayahuasca for sale, dmt tea, buy dmt and mescaline will induce internal hallucinations near consistently at level 5 geometry and above, 1P-LSD will for most simply go straight into Level 8A visual geometry. This lack of consistently induced hallucinatory breakthroughs means that for most, LSD is limited in depth
Is 1P LSD Legal?
1P LSD For Sale | Buy 1P LSD
Technically, 1P-LSD isn’t listed as a controlled substance in either Canada or the United States.
In both countries, you can order this substance from various sources online. In Canada, it’s very unlikely to experience any legal troubles for being in possession of this substance.
In the US, 1P-LSD could be considered illegal by the DEA under the Federal Analog Act because of its similarity to LSD-25. However, there have yet to be any convictions for the possession of 1P-LSD, and the DEA has never officially mentioned or made any statements about this compound.
Some countries in Europe have added 1P-LSD to their list of prohibited substances, including:
1P LSD Buy
- Buy 1P LSD France
- Finland
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- Estonia
- Japan
- Latvia
- Norway
- Romania
- Sweden
- Switzerland
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- The Czech Republic
How to Test 1P-LSD
You only need a small sample to do this effectively, so you aren’t really wasting any money or doses. Just a small sliver of one of your tabs is enough to perform the test.
Substance tests aren’t going to tell you the quality of a tab, but they will tell you if certain compounds are in it or not. The only dangerous compounds that are potent enough to fit on a single blotter paper are LSD and its analogs, NBOMe, or DOMx compounds.
It’s always a good idea to run multiple substance tests for LSD and 1P-LSD. The ideal would be all four mentioned below, but if you’re only going to run one or two, the Ehrlich and Marquis are the most important.

1. Ehrlich Test
This will show you whether the tab contains indole alkaloids (LSD, 1P-LSD, AL-LAD, or other derivatives) or not.
If you only run one test, this is the one.
Place one drop on a small sliver of the tab and wait for it to change color. It should turn purple or dark pink. LSD-25 usually turns right away, while 1P-LSD takes longer (up to 3 minutes).
If there’s no color change, your sample probably doesn’t contain any indole alkaloids and is therefore unsafe to use.

2. Marquis Reagent
The Marquis reagent will identify amphetamines, NBOMe, mescaline, and other substances in your sample. If it turns green, it likely contains NBOMe compounds and should be thrown out.
Follow the chart included in your Marquis test kit for the detection of other compounds.

3. Hofmann Reagent
It’s always a good idea to run two or more tests with different reagents just to make sure. The Hofmann reagent is used to differentiate certain indole alkaloids.
If the sample turns purple, it’s likely an LSD-derivative. If it turns green, it’s 5-MeO-DMT; if yellow, it’s N,N-DMT.

4. Mecke Reagent
The main role of the Mecke reagent is to determine whether there are any opiates in the sample. Since most opiates aren’t strong enough at sub-milligram doses, and the experience of these substances is nothing like LSD, it’s very unlikely for there to be any opiates in the sample.
This test is extra, just to be safe. It’s easy to run the Mecke test to make sure the sample doesn’t contain ultra-potent forms of opiates like fentanyl or kar-fentanyl.
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